California-based vaccine manufacturer PaxVax has reportedly submitted an application to begin international trials of a novel oral cholera vaccine that contains live, genetically modified (GM) bacteria. VacTruth.com reports that the new vaccine is set to be tested on more than 1,000 individuals, many of whom are young children, in a three-part clinical trial series to take place throughout Australia.
In a recent application filing with the Australian Government, PaxVax makes plain its intent to administer the live, GM bacteria in both young and old and in every region of the country. Participants will be instructed to literally consume a cocktail of mercury-resistant, GM Shigella flexneri NR1 bacteria derived from the Vibrio cholera bacterial strain, which is recognized as the causative agent of the gastroenteritis disease known as cholera.
According to the filing, the GM cholera strain used in the vaccine has essentially been artificially neutralized to prevent the toxic molecules that would otherwise cause the disease from being produced. The non-active B-subunit of the cholera toxin molecule, in other words, is reportedly still synthesized in the bacteria, but it allegedly no longer holds the capacity to induce either disease or toxicity.
"Multiple steps were required to produce the genetic modifications found in the GMO," explains the filing.
"Fragments of the Cholera toxin A subunit and haemolysin A genes were cloned into separate plasmids. The gene fragments were then modified in vitro by the deletion of part of the toxin gene and by the insertion of the mer operon. The plasmids were transferred into the V. cholerae, one at a time, and the genetic modifications were incorporated into the bacterial genome by recombination."
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